The benefits of wine without the calories.

• Maintains cell health
  
• Promotes normal cell cycle activity
  
• Promotes apoptosis (programmed cell death) in unhealthy cells
• Promotes normal nuclear factor kappa B (NF-Kappa B - protein) and cyclooxygenase-2 (COX-2 - enzyme) activity
  
• Promotes normal activity of the SIRT-1 gene (involved in calorie restriction, fat mobilization, mitochondrial function)
  
• Promotes cardiovascular health (promotes normal platelet activity, helps maintain normal vasorelaxation, provides antioxidant protection of LDL particles)
  
• Superior antioxidant and high ORAC value

Resveravine^® (resveratrol extract)
Resveratrol is a natural antioxidant found in red wine. Resveravine^® is a natural extract from Vitis vinifera standardized to contain 20% oligostilbenes. Resveravine^® is 100 to 300 times more concentrated in trans-resveratrol than other products made from grape skin. It provides antioxidant protection of low-density lipoprotein (LDL) particles, promotes normal platelet activity, vasorelaxation and blood flow, all which support cardiovascular health. It has been shown to promote apoptosis (programmed cell death) in unhealthy cells. Another proposed mechanism of action involves the study of the SIRT-1 gene (also known at the longevity gene). Sirtuins, known as Silent Information Regulators (SIRs), are deacetylase enzymes identified in all living creatures. Sirtuin proteins are known to play an important role in keeping regions of chromosomes turned off. Sirtuin controls the enzyme that converts acetate, a source of calories, into acetyl-CoA, a key component of cellular respiration. In humans, there are seven different sirtuins, SIRT-1 to SIRT-7. SIRT-1 has been studied by scientist for its potential effect on human cell lifespan.*

Resveratrol promotes normal activity of SIRT-1. Studies have shown that SIRT-1 activates a critical component of calorie restriction in mammals and promotes fat mobilization. The most recent study (Nature 2006) demonstrated that obese mice fed red wine extract (resveratrol) were in better health and lived longer than obese mice that were not fed the red wine extract. The resveratrol group was more able to maintain heart health compared to mice that were not fed resveratrol. SIRT-1 activation also supports healthy mitochondrial function and supports energy expenditure. Resveratrol has also been shown to have phytoestrogen activity and may support optimal estradiol activity. Other studies have documented neuroprotective benefits associated with resveratrol supplementation.* A comparison test was made to evaluate the activating effect on human SIRT-1 of Resveravine^® and pure trans-resveratrol. Only the trans-resveratrol form of the molecule promotes normal activation of the mammalian SIRT-1 gene in vitro test. Resveravine^® was more than eight times more likely to promote SIRT-1 activity than pure trans-resveratrol, showing that Resveravine^® is more efficient than resveratrol in promoting the normal activity of SIRT-1. Therefore, while the specific mechanisms of SIRT-1 and resveratrol are still unclear, the studies show that SIRT-1 is essential in lifespan extension and health improvement, and resveratrol promotes SIRT-1 activity.*

Studies in numerous species have demonstrated that reduction of calories 30 to 50 percent below ad libitium levels of a nutritious diet can promote a longer lifespan, improve overall health, promote normal stress resistance and decelerate functional decline. Studies showed that SIRT-1 activates a critical component of calorie restriction in mammals and promotes fat mobilization in adipocytes by repressing PPAR (test conducted on mice). Because healthy fat levels have been shown to promote a longer murine lifespan, it is suggested that calorie restriction could be connected to SIRT-1 and life extension in mammals. As an alternative strategy, new research has focused on the development of calorie restriction mimetics, compounds that mimic the effect of calorie restriction by targeting metabolic and stress response pathways affected by calorie restriction, but without restricting caloric intake. Resveratrol has been suggested as a potential calorie restriction mimetic. Supplementing mice with resveratrol significantly increases their aerobic capacity. By promoting healthy SIRT-1 activity, resveratrol promotes healthy mitochondrial function and supports energy expenditure, thereby promoting healthy weight. In vivo test conducted on mice on a high-calorie diet, resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and promotes their overall health.

BioVin^® Advanced (French Red Wine Extract with 5% resveratrol)
Red wine extract containing oligomeric proanthocyanins (OPCs), known to be extremely effective in supporting cardiovascular health by supporting normal blood circulation, strengthening blood vessels and promoting normal platelet activity. BioVin^® Advanced provides OPCs and additional Resveratrol. The red wine grape contains two main constituents shown to be of significant antioxidant value: red wine polyphenols (flavonoids) and trans-resveratrol (mentioned above). Oligomeric proanthocyanins are flavonoid complexes that act as super potent antioxidants in the human body. BioVin^® Advanced combines the antioxidant properties of OPCs with trans- resveratrol to promote phase 2 metabolizing enzymes, which are involved in the detoxification of the body's cells, promoting apoptosis (programmed cell death) in unhealthy cells, promoting healthy cholesterol levels and general free-radical scavenging properties.*

VitaBlue^® Wild Blueberry Extract (12.5% anthocyanins)
Blueberries rank highest among many fruits and vegetables for ORAC activity and contain 25-30 different types of anthocyanins. Anthocyanin gives blueberries (and other fruits) their rich blue and red coloring, and is a powerful flavonoid antioxidant. The mechanism of action surrounding anthocyanins has been studied at the molecular level, demonstrating effects such as the promotion of healthy cells and apoptosis (programmed cell death). Blueberries provide large amounts of chlorogenic acid, which is thought to be important in promoting cellular health. VitaBlue^® Wild Blueberry Extract supports the body's COX-2 inhibitors and provides powerful antioxidants in much higher quantities than fresh blueberries, and show to be effective in promoting cardiovascular health, contributing to normal cell cycle traverse, and maintaining overall cellular health.*

1. Resveratrol contains wine extracts. Is it alcohol free?
   Yes. Resveratrol is alcohol-free; there is no alcohol in this product.*
   
   
2. I am currently taking medication to manage my cholesterol. Can I still take Resveratrol?
   There are no documented interactions with cholesterol medication and any of the ingredients in Resveratrol. However, before taking any natural supplement, you should consult your physician.
   
   
3. Are there any contraindications for Isotonix Resveratrol?
   Yes. If you are currently taking warfarin (Coumadin) or other anti-platelet/anti-coagulant, you should not take this product. If you are taking any other prescription drugs or have an ongoing medical condition, you should consult your physician before using this product. Women who are pregnant or breastfeeding should not take this product.*
   
   
4. Can I take Resveratrol and still have a glass of wine with dinner?
   Yes. There is no cause of concern.*
   
   
5. I already take a multivitamin. Why do I need Resveratrol?
   Resveratrol is not a multivitamin. It is a product designed to promote optimal cell health and provide cardiovascular support.*
   
   
6. If I am an alcoholic, can I still take Resveratrol even though it is from red wine?
   Yes. Isotonix Resveratrol does not contain alcohol. Resveratrol is an extract from grape skins and vines that are used to make red wine.*
   
   
7. Will I get drunk from taking Resveratrol?
   No. Isotonix Resveratrol does not contain alcohol.
   
   
8. Is this product vegetarian-friendly?
   Yes. Isotonix Resveratrol is a vegetarian product.
   
   
9. Who should take this product?
   Clinical studies have shown that resveratrol extract may be helpful in promoting apoptosis (programmed cell death) in unhealthy cells, supporting normal cell cycle activity, promoting the normal activity of the SIRT-1 gene, thereby supporting overall cellular health. If you are interested in promoting cellular health and maintaining good cardiovascular health, then Isotonix Resveratrol is perfect for you.*
   
   
10. Can men and women take this product?
    Yes. However, women with a history of estrogen-sensitive cancers (breast, ovarian, uterine) should not take this product. Women who are pregnant or breastfeeding should not take this product.*
    
    
11. When should I start to see/feel the effects of this product? What should I expect?
    The antioxidant benefits of Isotonix Resveratrol should be noticeable in about four to six weeks. Please remember that everyone’s body is different, so for some it may take longer to notice the benefits of Resveratrol. You should expect to feel better and healthier overall.*
    
    
12. Do I need OPC-3 if I take this product?
    Isotonix OPC-3 is a superior antioxidant with many health benefits. Isotonix Resveratrol can be taken with other antioxidants; antioxidants work in several mechanisms and they build upon each other. For a complete comprehensive antioxidant defense, taking OPC-3 and Resveratrol is a smart choice protecting your body from the damaging effects of free radicals.*
    
    
13. What is the best way to store this product?
    Keep Isotonix stored in a dry, cool place. If Isotonix are stored in the kitchen, keep them away from the stove, sink, heat-generating appliances or window ledges. If you live in a very humid area, you may store Isotonix products in the refrigerator – but not in the fruit and vegetables area.

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